edexcel a level biology cystic fibrosisnorth walsham police station telephone number
New A level mocks service The lesson PowerPoints are highly detailed, and along with their accompanying worksheets, they have been planned at length to contain a wide range of engaging tasks which cover the following A-level Biology content found in topics 2, 3 and 6 of the course: This lesson describes how the expression of a gene mutation impairs the functioning of the organ systems in people with cystic fibrosis. This website and its content is subject to our Terms and If you would like to sample the quality of these lessons, then download the rapid gas exchange, osmosis, DNA & RNA, genetic code, genetic terms and cystic fibrosis lessons as these have been uploaded for free. The 20 lesson PowerPoints and accompanying resources contain a wide range of activities which cover the following topic 2 specification points: - cells from the chorionic villi collect through the abdomen with a needle or through the vagina with a catheter, Non-Invasive Prenatal Diagnosis ; Sammartino, J.C.; Poli, G.; Tuccinardi, T.; Beretta, G.; Porta, A.; et al. Cystic Fibrosis Mutation Database. For all these reasons, the identification of new therapeutic strategies that can support or refine the scarce antibiotic options available today is an imperative issue to be addressed. KMBT C454 20160622123319. In addition to the core practicals detailed below, possible experiments include investigation of the effect of surface area to volume ratio on uptake by diffusion, examination of slides of alveoli to observe the features that aid diffusion into the bloodstream, investigation of osmosis and diffusion across membranes, and investigation of inheritance using, for example, corn ears. Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients’ lungs. ; Pasca, M.R. Without these enzymes, the fat in food is not properly digested and it is difficult to gain weight. Compare that description to what students wear. Insertion mutations occur when a new nucleotide is added into a base sequence, Substitution mutations involve swapping one nucleotide for another, In duplication mutations entire genes can be duplicated, Inversion mutations result in the reversal of sections of DNA, Cystic fibrosis is a genetic disorder caused by a recessive allele, Cara graduated from the University of Exeter in 2005 with a degree in Biological Sciences. Medical applications and toxicities of gallium compounds. The cystic fibrosis patients are normally between 10 and 20. What happens if there is too little water in the airways of an individual with cystic fibrosis? Cara has taught in a range of secondary schools across the South West of England before joining the team at SME. What happens if there is excess water in the airways? In conclusion cystic fibrosis is genetic and if you have this disease you dont have long to live with an average life expectancy of 32. squamous (alveoli and capillaries) and columnar (small intestine), appearance of multiple layers due to nuclei when there is only one, apical membrane - cilia and mucus These people are called "carriers" of the CF gene. As you can see the percentage is falling. 5: 4635. [, Therefore, being as this preliminary evidence very promising, it is advisable to continue to study the use of NO as an alternative strategy to treat, Phage therapy (PT) represents an old idea which has acquired renewed importance thanks to the successful recent case reports, where antibiotic-resistant lung infections in CF people were treated [, PT refers to the use of phages to fight bacterial infections. St Pauls Place, Norfolk Street, Sheffield, S1 2JE. ; Griffith, D.E. These enzymes break down the fat. In order to be human-readable, please install an RSS reader. In recent years, there has been a renewed interest in the Western world in phage therapy as an alternative or addition to antibiotic therapy. It affects organs in the body, particularly the lungs and digestive system, which become clogged with sticky mucus, making it difficult to breathe and digest food. ; Switzer, B.; Hoke, T.; Moran, D.; Narayanasamy, P. In vitro efficacy of free and nanoparticle formulations of gallium(III) meso-tetraphenylporphyrine against. First assessment: 2017. permission provided that the original article is clearly cited. Brannon, J.R.; Hadjifrangiskou, M. The arsenal of pathogens and antivirulence therapeutic strategies for disarming them. Slavin, Y.N. Griffith, D.E. 3.18: Understand how cells become specialised through differential gene expression, producing active mRNA, leading to the synthesis of proteins which, in turn, control cell processes or determine cell structure in animals and plants ; Weimann, A.; Everall, I.; Bryant, J.M. ; et al. no miscarriage risk 2.13 (ii): Understand patterns of inheritance, including the interpretation of genetic pedigree diagrams, in the context of monohybrid inheritance Intracellular pathogens evolved to infect, colonise, and duplicate within host cells, managing to hide from the host immune system [, This lack of appropriate classical therapies has different causes, including antimicrobial resistance (AMR) which could have several mechanisms, such as the misuse of antimicrobials in both the healthcare and veterinary sectors. 2.11: Understand the nature of the genetic code An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. There are different ways that a mutation in the DNA base sequence can occur: Remember that every group of three bases in a DNA sequence codes for an amino acid, This means that insertion mutations cause what is known as a, Like an insertion mutation, a deletion mutation, Substitution mutations can take three forms, Note that a stop codon provides a signal for the cell to stop translation of the mRNA molecule into an amino acid sequence, Duplication is a type of mutation that involves the, A whole gene or section of a gene is duplicated so that, Overtime, the second copy can undergo mutations which enable it to develop new functions, Gene and chromosome duplications occur in all organisms, though they are, Inversion mutations usually occur during crossing-over in meiosis, The result is a large section of the gene that is 'backwards' and therefore multiple amino acids are affected, Inversion mutations frequently result in a non-functional protein, In some cases an entirely different protein is produced, The mutation is often harmful because the original gene can no longer be expressed from that chromosome, If the other chromosome in the pair carries a working gene the effect of the mutation may be lessened, The polypeptide can affect the phenotype, e.g. Recchia, D.; Stelitano, G.; Stamilla, A.; Gutierrez, D.L. Use of bacteriophages in the treatment of colistin-only-sensitive, Schooley, R.T.; Biswas, B.; Gill, J.J.; Hernandez-Morales, A.; Lancaster, J.; Lessor, L.; Barr, J.J.; Reed, S.L. ; Neves, R.C. How does cystic fibrosis affect the digestive system? the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, Please choose the one you're interested in: {{navigationJson.popularQualificationtitle}}, {{navigationJson.qualificationcolumnTitle1}}, {{navigationJson.qualificationcolumnTitle2}}, {{navigationJson.qualificationcolumnTitle3}}, ( Teaching Services team | Mon - Fri, 8am - 5pm GMT), {{ qualification.subjects.length }} qualifications, {{ qualification.subjects.length }} qualification, {{translateWord(navigationJson.covidTitle)}}, {{translateWord(navigationJson.subjectTitle)}}, {{translateWord(navigationJson.qualificationTitle)}}, {{navigationJson.qualificationcolumn1CTAtext}}, {{navigationJson.qualificationcolumn2CTAtext}}, {{navigationJson.qualificationcolumn3CTAtext}}, {{translateWord(navigationJson.supportTitle)}}, {{translateWord(navigationJson.aboutusTitle)}}, {{translateWord(navigationJson.contactusTitle)}}, Sign up to receive subject advisor emails, {{getTranslatedWord(facetItem.formattedFacetValue)}} ({{facetItem.count}}), {{ qualification.title | titleCaseFilter }}, {{spec.title | cleanTitle }} ({{spec.qfTitle | titleCaseFilter}}), {{spec.title | cleanTitle}} ({{spec.qfTitle | titleCaseFilter}}). ; Rao, J.R.; Moore, J.E. Mencarini, J.; Cresci, C.; Simonetti, M.T. * Understand how the expression of a gene mutation in people with cystic fibrosis impairs the functioning of the gaseous exchange, digestive and reproductive systems Cystic Fibrosis is caused by a single faulty gene that controls the movement of salt in the body [4]. Signup as a free member below and you'll be brought back to this page to try the sample materials before you buy. In short, there is still a long way to go before these therapies can become part of the clinical treatment of these infections. * The basic structure of mononucleotides If you're ready to pass your Edexcel A-Level Biology exams, become a member now to get complete access to our entire library of revision materials. Int. The aim is to provide a snapshot of some of the It states that 'the rate of diffusion is proportional to both the surface area and . ; Riabova, O.; Makarov, V.; Pasca, M.R. Make a quick list of five to ten clothing items that you've thought about owning. ; and funding acquisition, M.R.P. This can put a person with cystic fibrosis at risk of getting bacterial chest infections. in 2013 reported an MIC of 25 g/mL against, More specific research analyses 22 pure compounds extracted from different parts of 4 medicinal plants (, All the reported studies indicate that plants and fungi are still nowadays a source with a huge potential for discovering new molecules that are effective in fighting, In conclusion, this review provides an overview of the latest findings on innovative therapies against, For some of the strategies described, positive results have been obtained at the early pre-clinical stages, and it is hoped that these will form the basis for developing these strategies and confirming their efficacy in vivo so that they can reach the clinical trial stage. Fang, F.C. 3.8 (i): The loci is a location of genes on a chromosome Grasemann, H.; Grasemann, C.; Kurtz, F.; Tietze-Schillings, G.; Vester, U.; Ratjen, F. Oral L-arginine supplementation in cystic fibrosis patients: A placebo-controlled study. Hours and hours of planning have gone into each and every lesson that's included in this bundle to ensure that the students are engaged and motivated whilst the detailed content of topic 2 of the Edexcel International A-level Biology specification is covered. ; Savant, A.P. Locate the section on student dress in your school handbook. ; Rendon, A.; Franco, I. Non-tuberculous mycobacterial pulmonary infections. What type of allele causes cystic fibrosis? She has 8 years of classroom experience teaching Key Stage 3 up to A-Level biology, and is currently a tutor and A-Level examiner. ; Sennato, S.; De Santis, F.; Forte, J.; Fraziano, M.; Casciardi, S.; Marianecci, C.; Bordi, F.; Carafa, M. Rifampicin-liposomes for, Poerio, N.; Riva, C.; Olimpieri, T.; Rossi, M.; Lor, N.I. * A gene is a sequence of bases on DNA that codes for the amino acid sequence of a polypeptide Judson, I.; Radford, J.A. This case study is about Cystic Fibrosis is abortion of a cystic fibrosis child ethical. The Cystic Fibrosis Foundation is a . A Science teacher by trade, I've also been known to be found teaching Maths and PE! * Adaptations of the mammalian lung for rapid gaseous exchange Antimycobacterial activity of a new peptide polydim-i isolated from neotropical social wasp, Silva, J.C.; Neto, L.M. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. I have come to the end of my case study hope you enjoyed it, thank you. * A gene as a sequence of bases on DNA that codes for a sequence of amino acids In each cell in our bodies we have 22 pairs of chromosomes and one pair of sex chromosomes. Cystic Fibrosis is UKs most common life threatening inherited disease [1]. Going through the ppt I recognised your style from some revision materials I purchased some time back which were also very good. 2.8: Know that a gene is a sequence of bases on a DNA molecule that codes for a sequence of amino acids in a polypeptide chain ; Rueckes-Nilges, C.; et al. * Enzymes are biological catalysts it could form part of an enzyme or a membrane transport protein, Because cystic fibrosis is determined by a, Mucus in the respiratory system is a necessary part of keeping the lungs healthy, It prevents infection by trapping microorganisms, This mucus is moved out of the respiratory tract by cilia, In people with cystic fibrosis, due to the faulty chloride ion channels, the, This means microorganisms are not efficiently removed from the lungs and lung infections occur more frequently, Thick mucus in the digestive system can cause issues because, Digestion of some food may be reduced and therefore, Mucus is normally secreted in the reproductive system to prevent infection and regulate the progress of sperm through the reproductive tract after sexual intercourse, The mucus in people with cystic fibrosis can cause issues in both men and women. 8. * The nature of the genetic code Chan, B.K. ; Rose, T.; Keersebilck, E.; Soete, O.; Francois, P.M.; Teodorescu, S.; Verween, G.; et al. The main focus of the lesson is the CFTR gene and the functions of the ion channel that is synthesised when this gene is expressed. This research was funded by the Italian Cystic Fibrosis Foundation, grant number FFC#18/2021 (adopted by Delegazione FFC Ricerca di Codogno e Piacenza, Delegazione FFC Ricerca di Rovigo, Delegazione FFC Ricerca di Belluno, Nonno Nanni Latteria Montello), and FFC#5/2022 (adopted by: Gruppo di sostegno FFC Ricerca Miriam ColomboOspedaletti; Gruppo di sostegno FFC Ricerca di GradoGorizia; Gruppo di sostegno FFC Ricerca di Benevento; Delegazione FFC Ricerca di Monterotondo Roma; Delegazione FFC Ricerca di Vigevano; Delegazione FFC Ricerca di Trieste; Delegazione FFC Ricerca di Sassari Castelsardo; Delegazione FFC Ricerca di Moncalvo; Delegazione FFC Ricerca di Lecce). future research directions and describes possible research applications. You are accessing a machine-readable page. Although the majority of the lesson is described with reference to the gaseous exchange system, the impaired functioning of the digestive system in terms of the blockage of the pancreas and liver secretions is considered and discussed and the students are challenged on their understanding through a range of exam-style questions. Membranes, proteins, DNA and gene expression represent some of the most important structures, molecules and processes involved in this subject and a deep understanding of their role in living organisms is important for a student's success. Another cause of AMR is the poor pharmacokinetics of many classical drugs, due to difficulty in reaching the site of action; as a result, subcellular niches used by infecting bacteria are not reached by most current drugs. ; Gupta, S.; Olivier, K.N. About 70% of mutations observed in CF patients result from deletion of three base pairs in CFTR's nucleotide sequence. 2.14 (ii): Know that some mutations will give rise to cancer or genetic disorders, but that many mutations will have no observable effect First assessment: 2016. The chloride channel is made from a protein called, (CFTR) protein. ; et al. A-level Biology) This lesson bundle contains 16 lessons which have been designed to cover the Edexcel International A-level Biology specification points which focus on the structure of DNA and RNA, their roles in replication and protein synthesis, and genetics and inheritance.
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